Intermittent stimulation in the nucleus basalis of meynert improves sustained attention in rhesus monkeys
نویسندگان
چکیده
منابع مشابه
Potential for intermittent stimulation of nucleus basalis of Meynert to impact treatment of alzheimer's disease
The brain's cholinergic arousal pathways decline in parallel with the brain's executive functions in aging and Alzheimer's Disease. The frontline and currently most effective approach to treating Alzheimer's disease is the administration of cholinesterase inhibitors, which, in a dose dependent manner, improve the symptoms of cognitive decline over the first months of treatment before further de...
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ADAS-cog 1⁄4 Alzheimer’s disease Assessment Scale, MMSE 1⁄4Mini Mental Status Examination, RWT 1⁄4 Regensburger Wortschatz Test, WAIS 1⁄4 Wechsler Adult Intelligence Scale, WMS 1⁄4 Wechsler Memory Scale, BDI II 1⁄4 Beck’s Depression Inventory (2nd edition), HAMD 1⁄4 Hamilton Depression Rating Scale, FAST 1⁄4 Florida Apraxia Screening Test. a A lower value represents a better outcome. b A higher...
متن کاملStimulation of NMDA and AMPA receptors in the rat nucleus basalis of Meynert affects sleep.
The nucleus basalis of Meynert (NBM), a heterogeneous area in the basal forebrain involved in the modulation of sleep and wakefulness, is rich in glutamate receptors, and glutamatergic fibers represent an important part of the input to this nucleus. With the use of unilateral infusions in the NBM, the effects of two different glutamatergic subtype agonists, namely N-methyl-d-aspartic acid (NMDA...
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OBJECTIVE Deep brain stimulation (DBS) is a therapeutically effective neurosurgical method originally applied in movement disorders. Over time, the application of DBS has increasingly been considered as a therapeutic option for several neuropsychiatric disorders, including Gilles de la Tourette syndrome, obsessive compulsive disorder, major depression and addiction. Latest research suggests ben...
متن کاملComparative analysis of the nucleus basalis of Meynert among primates.
Long projection axons from the Ch4 cell group of the nucleus basalis of Meynert (nbM) provide cholinergic innervation to the neurons of the cerebral cortex. This cortical cholinergic innervation has been implicated in behavioral and cognitive functions, including learning and memory. Recent evidence revealed differences among primate species in the pattern of cholinergic innervation specific to...
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ژورنال
عنوان ژورنال: Neuropharmacology
سال: 2018
ISSN: 0028-3908
DOI: 10.1016/j.neuropharm.2018.04.026